Adams, D. J. , Clark, J. H., Heath, P. A., Hansen, L. B., Sanders, V. C. and Tavener, S. J. (2000) Novel synthetic methodologies for fluorination and perfluoroalkylation. Journal of Fluorine Chemistry, 101(2), pp. 187-191. (doi: 10.1016/S0022-1139(99)00157-8)
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Abstract
Nucleophilic routes to selectively fluorinated aromatic compounds starting from cheap and readily available nitroaromatics are reviewed. Me3SiCF3, in conjunction with a fluoride, can be used as either a fluorinating or trifluoromethylating agent, and is capable of both the trifluoromethyldenitration and trifluoromethyldecyanation of an aromatic molecule. Nucleophilic trifluoromethylthiolation can be achieved using thiophosgene and a fluoride.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Adams, Dave |
| Authors: | Adams, D. J., Clark, J. H., Heath, P. A., Hansen, L. B., Sanders, V. C., and Tavener, S. J. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Journal of Fluorine Chemistry |
| Publisher: | Elsevier |
| ISSN: | 0022-1139 |
| ISSN (Online): | 1873-3328 |
| Published Online: | 14 December 1999 |
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