Novel synthetic methodologies for fluorination and perfluoroalkylation

Adams, D. J. , Clark, J. H., Heath, P. A., Hansen, L. B., Sanders, V. C. and Tavener, S. J. (2000) Novel synthetic methodologies for fluorination and perfluoroalkylation. Journal of Fluorine Chemistry, 101(2), pp. 187-191. (doi:10.1016/S0022-1139(99)00157-8)

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Abstract

Nucleophilic routes to selectively fluorinated aromatic compounds starting from cheap and readily available nitroaromatics are reviewed. Me3SiCF3, in conjunction with a fluoride, can be used as either a fluorinating or trifluoromethylating agent, and is capable of both the trifluoromethyldenitration and trifluoromethyldecyanation of an aromatic molecule. Nucleophilic trifluoromethylthiolation can be achieved using thiophosgene and a fluoride.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Adams, Dave
Authors: Adams, D. J., Clark, J. H., Heath, P. A., Hansen, L. B., Sanders, V. C., and Tavener, S. J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Journal of Fluorine Chemistry
Publisher:Elsevier
ISSN:0022-1139
ISSN (Online):1873-3328
Published Online:14 December 1999

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