Ivermectin - old drug, new tricks?

Laing, R., Gillan, V. and Devaney, E. (2017) Ivermectin - old drug, new tricks? Trends in Parasitology, 33(6), pp. 463-472. (doi:10.1016/j.pt.2017.02.004) (PMID:28285851) (PMCID:PMC5446326)

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Abstract

Ivermectin is one of the most important drugs in veterinary and human medicine for the control of parasitic infection and was the joint focus of the 2015 Nobel Prize in Physiology or Medicine, some 35 years after its remarkable discovery. Although best described for its activity on glutamate-gated chloride channels in parasitic nematodes, understanding of its mode of action remains incomplete. In the field of veterinary medicine, resistance to ivermectin is now widespread, but the mechanisms underlying resistance are unresolved. Here we discuss the history of this versatile drug and its use in global health. Based on recent studies in a variety of systems, we question whether ivermectin could have additional modes of action on parasitic nematodes.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Devaney, Professor Eileen and Gillan, Dr Victoria and Laing, Dr Rosalind
Authors: Laing, R., Gillan, V., and Devaney, E.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Trends in Parasitology
Publisher:Elsevier
ISSN:1471-4922
ISSN (Online):1471-5007
Published Online:09 March 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Trends in Parasitology 33(6): 463-472
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
636401The BUG consortium Building Upon the Genome: using H. contortus genomic resources to develop novel interventions to control endemic GI parasitesEileen DevaneyBiotechnology and Biological Sciences Research Council (BBSRC)BB/M003949/1RI BIODIVERSITY ANIMAL HEALTH & COMPMED