Self-assembly of surfactant-like peptides

Adams, D. J. , Holtzmann, K., Schneider, C. and Butler, M. F. (2007) Self-assembly of surfactant-like peptides. Langmuir, 23(25), pp. 12729-12736. (doi: 10.1021/la7011183) (PMID:17988158)

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Inspired by recent work describing surfactant-like peptides, we have carried out a systematic study on peptides with the underlying composition of V6D2, altering the absolute sequence to determine the importance of the surfactant-like structure. All of the peptides examined here formed self-assembled structures in water. However, in contrast to other reports, we have found a surprising diversity of structures including fibers, tapes, and twisted ribbons but an absence of the vesicles and nanotubes described previously. Further investigations demonstrated that peptide purity plays a significant role in the outcome of the self-assembly. Different batches behave very differently, which can be linked to the compositions of these batches. This work shows that there is a need for not only rational design but also ease of synthesis of the building blocks for self-assembled structures.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Adams, Dave
Authors: Adams, D. J., Holtzmann, K., Schneider, C., and Butler, M. F.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Langmuir
Publisher:American Chemical Society
ISSN (Online):1520-5827
Published Online:08 November 2007

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