Oligopeptide-based amide functional initiators for ATRP

Adams, D. J. and Young, I. (2008) Oligopeptide-based amide functional initiators for ATRP. Journal of Polymer Science Part A: Polymer Chemistry, 46(18), pp. 6082-6090. (doi:10.1002/pola.22920)

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Abstract

Polymer–peptide conjugates are receiving significant interest. Here, we show that, under the appropriate conditions, a small family of oligopeptide-based initiators can be used successfully to initiate the polymerization of methacrylic monomers by atom transfer radical polymerization (ATRP), generating new examples of such materials. However, the use of the peptidic amide-based initiators results in polymers which have a higher molecular weight than expected and a significantly higher polydispersity than those prepared from ester-based initiators. In many cases significant initiator remains, suggesting that either not all peptides successfully initiate polymerization or that significant termination reactions occur early in the reaction. This low initiator efficiency agrees with other reports for amino acid-based initiators. It therefore appears that such amide-based initiators can be used successfully, but have a significantly lower applicability than the more commonly used ester-based initiators.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Adams, Dave
Authors: Adams, D. J., and Young, I.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Journal of Polymer Science Part A: Polymer Chemistry
Publisher:Wiley
ISSN:0887-624X
ISSN (Online):1099-0518
Published Online:12 August 2008

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