Directed self-assembly of dipeptides to form ultrathin hydrogel membranes

Johnson, E. K., Adams, D. J. and Cameron, P. J. (2010) Directed self-assembly of dipeptides to form ultrathin hydrogel membranes. Journal of the American Chemical Society, 132(14), pp. 5130-5136. (doi: 10.1021/ja909579p) (PMID:20307067)

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The dipeptide amphiphile Fmoc-Leu-Gly-OH has been induced to self-assemble into thin surface-supported hydrogel gel films and gap-spanning hydrogel membranes. The thickness can be closely controlled, giving films/membranes from tens of nanometers to millimeters thick. SEM and TEM have confirmed that the dipeptides self-assemble to form fibers, with the membranes resembling a dense “mat” of entangled fibers. The films and membranes were stable once formed. The films could be reversibly dried and collapsed, then reswollen to regain the gel structure.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Adams, Dave
Authors: Johnson, E. K., Adams, D. J., and Cameron, P. J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Journal of the American Chemical Society
Publisher:American Chemical Society
ISSN (Online):1520-5126
Published Online:22 March 2010

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