Impact of mechanism of formation on encapsulation in block copolymer vesicles

Adams, D. J. , Adams, S., Atkins, D., Butler, M. F. and Furzeland, S. (2008) Impact of mechanism of formation on encapsulation in block copolymer vesicles. Journal of Controlled Release, 128(2), pp. 165-170. (doi:10.1016/j.jconrel.2008.03.006) (PMID:18436325)

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Abstract

Vesicles prepared from block copolymers have been mooted for the encapsulation of water-soluble molecules. This is because the membranes of polymer vesicles have been shown to be more stable than those in vesicles formed from lipids, with the membrane properties being tuned by the length and nature of the hydrophobic block in the polymer. The generally accepted mechanisms of vesicle formation involve either wrap-up of a lamellar sheet or formation via a sequence of micelle to worm to disks to vesicles. These should lead to efficient encapsulation. Alternatively, a method involving phase separation followed by re-structuring has been recently suggested. Here, we show that this final mechanism holds for vesicles formed from a PEO-b-PDEAMA copolymer by a pH switch and that this mechanism leads to highly inefficient encapsulation on vesicle formation.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Adams, Dave
Authors: Adams, D. J., Adams, S., Atkins, D., Butler, M. F., and Furzeland, S.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Journal of Controlled Release
Publisher:Elsevier
ISSN:0168-3659
ISSN (Online):1873-4995
Published Online:14 March 2008

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