Tzokova, N., Fernyhough, C. M., Butler, M. F., Armes, S. P., Ryan, A. J., Topham, P. D. and Adams, D. J. (2009) The effect of PEO length on the self-assembly of poly(ethylene oxide)−tetrapeptide conjugates prepared by “Click” chemistry. Langmuir, 25(18), pp. 11082-11089. (doi: 10.1021/la901413n) (PMID:19685857)
Full text not currently available from Enlighten.
Abstract
Two series of poly(ethylene oxide)−tetrapeptide conjugates have been prepared using a “Click” reaction between an alkyne-modified tetra(phenylalanine) or tetra(valine) and various azide-terminated poly(ethylene oxide) (PEO) oligomers. Three different PEO precursors were used to prepare these conjugates, with number-average molecular weights of 350, 1200, and 1800 Da. Assembly of mPEO−F4−OEt and mPEO−V4−OEt conjugates was achieved by dialysis of a THF solution of the conjugate against water or by direct aqueous rehydration of a thin film. The PEO length has a profound effect on the outcome of the self-assembly, with the F4 conjugates giving rise to nanotubes, fibers, and wormlike micelles, respectively, as the length of the PEO block is increased. For the V4 series, the propensity to form β-sheets dominates, and hence, the self-assembled structures are reminiscent of those formed by peptides alone, even at the longer PEO lengths. Thus, this systematic study demonstrates that the self-assembly of PEO−peptides depends on both the nature of the peptides and the relative PEO block length.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Adams, Dave |
Authors: | Tzokova, N., Fernyhough, C. M., Butler, M. F., Armes, S. P., Ryan, A. J., Topham, P. D., and Adams, D. J. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Langmuir |
Publisher: | American Chemical Society |
ISSN: | 0743-7463 |
ISSN (Online): | 1520-5827 |
Published Online: | 17 August 2009 |
University Staff: Request a correction | Enlighten Editors: Update this record