Polymer nanoparticles: shape-directed monomer-to-particle synthesis

He, T., Adams, D. J. , Butler, M. F., Cooper, A. I. and Rannard, S. P. (2009) Polymer nanoparticles: shape-directed monomer-to-particle synthesis. Journal of the American Chemical Society, 131(4), pp. 1495-1501. (doi: 10.1021/ja807462e) (PMID:19133746)

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Well-defined dumbbell and tripartite organic nanoparticles (30−60 nm) were produced via a one-pot direct synthesis of branched amphiphilic block copolymers, avoiding the need for postsynthesis self-assembly steps. We show the mechanism of dumbbell formation is largely a concerted process of particle growth during polymerization, although data suggest that particle−particle linking also occurs, particularly at higher monomer conversions. Dumbbell particles formed using a disulfide bifunctional initiator lead to cleavable structures, underlining the role of initiator functionality in shape control and the potential for functionality placement. Trifunctional initiators allow the direct one-pot synthesis of “tripartite” clover-leaf shaped nanoparticles which would be difficult to achieve through conventional synthesis/self-assembly/cross-linking strategies.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Adams, Dave
Authors: He, T., Adams, D. J., Butler, M. F., Cooper, A. I., and Rannard, S. P.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Journal of the American Chemical Society
Publisher:American Chemical Society
ISSN (Online):1520-5126
Published Online:09 January 2009

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