STROKOG (stroke and cognition consortium): an international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease

Sachdev, P. S. et al. (2017) STROKOG (stroke and cognition consortium): an international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease. Alzheimer's and Dementia, 7, pp. 11-23. (doi: 10.1016/j.dadm.2016.10.006) (PMID:28138511) (PMCID:PMC5257024)

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Abstract

Introduction: The Stroke and Cognition consortium (STROKOG) aims to facilitate a better understanding of the determinants of vascular contributions to cognitive disorders and help improve the diagnosis and treatment of vascular cognitive disorders (VCD). Methods: Longitudinal studies with ≥75 participants who had suffered or were at risk of stroke or TIA and which evaluated cognitive function were invited to join STROKOG. The consortium will facilitate projects investigating rates and patterns of cognitive decline, risk factors for VCD, and biomarkers of vascular dementia. Results: Currently, STROKOG includes 25 (21 published) studies, with 12,092 participants from five continents. The duration of follow-up ranges from 3 months to 21 years. Discussion: Although data harmonization will be a key challenge, STROKOG is in a unique position to reuse and combine international cohort data and fully explore patient level characteristics and outcomes. STROKOG could potentially transform our understanding of VCD and have a worldwide impact on promoting better vascular cognitive outcomes.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Makin, Dr Stephen and Stott J, Professor David
Authors: Sachdev, P. S., Lo, J. W., Crawford, J. D., Mellon, L., Hickey, A., Williams, D., Bordet, R., Mendyk, A.-M., Gelé, P., Deplanque, D., Bae, H.-J., Lim, J.-S., Brodtmann, A., Werden, E., Cumming, T., Köhler, S., Verhey, F. R.J., Dong, Y.-H., Tan, H. H., Chen, C., Xin, X., Kalaria, R. N., Allan, L. M., Akinyemi, R. O., Ogunniyi, A., Klimkowicz-Mrowiec, A., Dichgans, M., Wollenweber, F. A., Zietemann, V., Hoffmann, M., Desmond, D. W., Linden, T., Blomstrand, C., Fagerberg, B., Skoog, I., Godefroy, O., Barbay, M., Roussel, M., Lee, B.-C., Yu, K.-H., Wardlaw, J., Makin, S. J., Doubal, F. N., Chappell, F. M., Srikanth, V. K., Thrift, A. G., Donnan, G. A., Kandiah, N., Chander, R. J., Lin, X., Cordonnier, C., Moulin, S., Rossi, C., Sabayan, B., Stott, D. J., Jukema, J. W., Melkas, S., Jokinen, H., Erkinjuntti, T., Mok, V. C.T., Wong, A., Lam, B. Y.K., Leys, D., Hénon, H., Bombois, S., Lipnicki, D. M., and Kochan, N. A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Alzheimer's and Dementia
Publisher:Elsevier
ISSN:1552-5260
ISSN (Online):1552-5279
Published Online:18 November 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Alzheimer's and Dementia 7: 11-23
Publisher Policy:Reproduced under a Creative Commons License

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