Gating of memory encoding of time-delayed cross-frequency MEG networks revealed by graph filtration based on persistent homology

Hahm, J., Lee, H., Park, H. , Kang, E., Kim, Y. K., Chung, C. K., Kang, H. and Lee, D. S. (2017) Gating of memory encoding of time-delayed cross-frequency MEG networks revealed by graph filtration based on persistent homology. Scientific Reports, 7, 41592. (doi: 10.1038/srep41592) (PMID:28169281) (PMCID:PMC5294648)

Abstract

To explain gating of memory encoding, magnetoencephalography (MEG) was analyzed over multi-regional network of negative correlations between alpha band power during cue (cue-alpha) and gamma band power during item presentation (item-gamma) in Remember (R) and No-remember (NR) condition. Persistent homology with graph filtration on alpha-gamma correlation disclosed topological invariants to explain memory gating. Instruction compliance (R-hits minus NR-hits) was significantly related to negative coupling between the left superior occipital (cue-alpha) and the left dorsolateral superior frontal gyri (item-gamma) on permutation test, where the coupling was stronger in R than NR. In good memory performers (R-hits minus false alarm), the coupling was stronger in R than NR between the right posterior cingulate (cue-alpha) and the left fusiform gyri (item-gamma). Gating of memory encoding was dictated by inter-regional negative alpha-gamma coupling. Our graph filtration over MEG network revealed these inter-regional time-delayed cross-frequency connectivity serve gating of memory encoding.

• Item Type: Articles
• Additional Information: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2013R1A1A2057782) and also by the NRF grant funded by the Korea government (MEST) (No. 2011-0030815 and 2015M3C7A1028926). We thank Professor Cheongtag Kim (Department of Psychology, Seoul National University, Seoul, Republic of Korea) for his valuable comments on the manuscript.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Park, Dr Hyojin
• Authors: Hahm, J., Lee, H., Park, H., Kang, E., Kim, Y. K., Chung, C. K., Kang, H., and Lee, D. S.
• Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
• College/School: College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
• Journal Name: Scientific Reports
• Publisher: Nature Research
• ISSN: 2045-2322
• ISSN (Online): 2045-2322
• Published Online: 07 February 2017
• Copyright Holders: Copyright © 2017 The Authors
• First Published: First published in Scientific Reports 7: 41592
• Publisher Policy: Reproduced under a Creative Commons License