Michels, C. E., Scales, H. E. , Saunders, K. A., McGowan, S., Brombracher, F., Alexander, J. and Lawrence, C. E. (2008) Neither interleukin-4 receptor α expression on CD4+ T cells, or macrophages and neutrophils is required for protective immunity to Trichinella spiralis. Immunology, 128(1pt2), e385-e394. (doi: 10.1111/j.1365-2567.2008.02987.x) (PMID:19191917)
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Abstract
The T helper type 2 (Th2) mediated expulsion of the gastrointestinal nematode Trichinella spiralis requires interleukin-4 receptor α (IL-4Rα) expression on both bone-marrow-derived and non-bone-marrow-derived cells. To more definitively investigate the role of IL-4/IL-13 responsiveness in the development of protective immunity to T. spiralis, cell-specific IL-4Rα signalling on CD4+ T cells (Lckcre IL-4Rα−/flox) and macrophages/neutrophils (LysMcre IL-4Rα−/flox) was analysed on the BALB/c background. Infection of wild-type and control IL-4Rα−/flox mice induced a Th2-type immune response with elevated IL-4 cytokine production, parasite-specific immunoglobulin G1 (IgG1), total IgE, intestinal mastocytosis and enteropathy. In contrast, global IL-4Rα-deficient BALB/c mice showed reduced worm expulsion, antibody production, intestinal mastocytosis and gut pathology. BALB/c mice generated with cell-specific deletion of IL-4Rα on CD4+ T lymphocytes or macrophages/neutrophils, controlled gastrointestinal helminth infection by eliciting a protective immune response comparable to that observed with wild-type and IL-4Rα−/flox controls. Together, this shows that the development of host protective Th2 responses accompanied by parasite loss is independent of IL-4Rα expression on CD4+ T cells and macrophages/neutrophils.
| Item Type: | Articles |
|---|---|
| Keywords: | Cell-specific interleukin-4 receptor α transgenic mice, gastrointestinal nematodes, mastocytosis, T helper immune response, Trichinella spiralis |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Michels, Dr Chesney and Scales, Dr Hannah |
| Authors: | Michels, C. E., Scales, H. E., Saunders, K. A., McGowan, S., Brombracher, F., Alexander, J., and Lawrence, C. E. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Immunology |
| Publisher: | Wiley |
| ISSN: | 0019-2805 |
| ISSN (Online): | 1365-2567 |
| Published Online: | 16 December 2008 |
| Published Online: | 01 January 2009 |
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