Mitogenome diversity in Sardinians: a genetic window onto an island's past

Olivieri, A. et al. (2017) Mitogenome diversity in Sardinians: a genetic window onto an island's past. Molecular Biology and Evolution, (doi:10.1093/molbev/msx082) (PMID:28177087) (Early Online Publication)

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Abstract

Sardinians are “outliers” in the European genetic landscape and, according to paleogenomic nuclear data, the closest to early European Neolithic farmers. To learn more about their genetic ancestry, we analyzed 3,491 modern and 21 ancient mitogenomes from Sardinia. We observed that 78.4% of modern mitogenomes cluster into 89 haplogroups that most likely arose in situ. For each Sardinian-Specific Haplogroup (SSH), we also identified the upstream node in the phylogeny, from which non-Sardinian mitogenomes radiate. This provided minimum and maximum time estimates for the presence of each SSH on the island. In agreement with demographic evidence, almost all SSHs coalesce in the post-Nuragic, Nuragic and Neolithic-Copper Age periods. For some rare SSHs, however, we could not dismiss the possibility that they might have been on the island prior to the Neolithic, a scenario that would be in agreement with archeological evidence of a Mesolithic occupation of Sardinia.

Item Type:Articles
Status:Early Online Publication
Refereed:Yes
Glasgow Author(s) Enlighten ID:Macaulay, Dr Vincent
Authors: Olivieri, A., Sidore, C., Achilli, A., Angius, A., Posth, C., Furtwängler, A., Brandini, S., Capodiferro, M. R., Gandini, F., Zoledziewska, M., Pitzalis, M., Maschio, A., Busonero, F., Lai, L., Skeates, R., Gradoli, M. G., Beckett, J., Marongiu, M., Mazzarello, V., Marongiu, P., Rubino, S., Rito, T., Macaulay, V., Semino, O., Pala, M., Abecasis, G. R., Schlessinger, D., Conde-Sousa, E., Soares, P., Richards, M. B., Cucca, F., and Torroni, A.
College/School:College of Science and Engineering > School of Mathematics and Statistics > Statistics
Journal Name:Molecular Biology and Evolution
Publisher:Oxford University Press
ISSN:0737-4038
ISSN (Online):1537-1719
Published Online:08 February 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Molecular Biology and Evolution 2017
Publisher Policy:Reproduced under a Creative Commons License

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