The Youth Mental Health Risk and Resilience Study (YouR-Study)

Uhlhaas, P. J. , Gajwani, R., Gross, J. , Gumley, A. I. , Lawrie, S. M. and Schwannauer, M. (2017) The Youth Mental Health Risk and Resilience Study (YouR-Study). BMC Psychiatry, 17, 43. (doi:10.1186/s12888-017-1206-5) (PMID:28125984) (PMCID:PMC5270216)

Uhlhaas, P. J. , Gajwani, R., Gross, J. , Gumley, A. I. , Lawrie, S. M. and Schwannauer, M. (2017) The Youth Mental Health Risk and Resilience Study (YouR-Study). BMC Psychiatry, 17, 43. (doi:10.1186/s12888-017-1206-5) (PMID:28125984) (PMCID:PMC5270216)

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Abstract

Background: The transition from adolescence to adulthood is associated with the emergence of psychosis and other mental health problems, highlighting the importance of this developmental period for the understanding of developing psychopathology and individual differences in risk and resilience. The Youth Mental Health Risk and Resilience Study (YouR-Study) aims to identify neurobiological mechanisms and predictors of psychosis-risk with a state-of-the-art neuroimaging approach (Magnetoencephalography, Magnetic Resonance Spectroscopy, Magnetic Resonance Imaging) in combination with core psychological processes, such as affect regulation and attachment, that have been implicated in the development and maintenance of severe mental health problems. Methods/Design: One hundred participants meeting clinical high-risk criteria (CHR) for psychosis through the Comprehensive Assessment of At-Risk Mental State and Schizophrenia Proneness Instrument, Adult Version, in the age range from 16 to 35 years of age will be recruited. Mental-state monitoring up to a total of 2 years will be implemented to detect transition to psychosis. In addition, a sample of n = 40 help-seeking participants will be recruited who do not meet CHR-criteria, a group of n = 50 healthy control participants and a sample of n = 25 patients with first-episode psychosis. MEG-activity will be obtained during auditory and visual tasks to examine neural oscillations and event-related fields. In addition, we will obtain estimates of GABA and Glutamate levels through Magnetic Resonance Spectroscopy (MRS) to examine relationships between neural synchrony and excitatory-inhibition (E/I) balance parameters. Neuroimaging will be complemented by detailed neuropsychological assessments as well as psychological measures investigating the impact of childhood abuse, attachment experiences and affect regulation. Discussion: The YouR-study could potentially provide important insights into the neurobiological mechanisms that confer risk for psychosis as well as biomarkers for early diagnosis of severe mental health problems. Moreover, we expect novel data related to the contribution of affect regulation and attachment-processes in the development of mental health problems, leading to an integrative model of early stage psychosis and the factors underlying risk and resilience of emerging psychopathology.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Uhlhaas, Professor Peter and Gross, Professor Joachim and Gumley, Professor Andrew and Gajwani, Dr Ruchika
Authors: Uhlhaas, P. J., Gajwani, R., Gross, J., Gumley, A. I., Lawrie, S. M., and Schwannauer, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:BMC Psychiatry
Publisher:BioMed Central
ISSN:1471-244X
ISSN (Online):1471-244X
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in BMC Psychiatry 17:43
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
640691Using Magnetoencephalography to Investigate Aberrant Neural Synchrony in Prodromal Schizophrenia: A Translational Biomarker ApproachPeter UhlhaasMedical Research Council (MRC)MR/L011689/1RI NEUROSCIENCE & PSYCHOLOGY