The effect of atrial natriuretic factor on urinary albumin and β2-microglobulin excretion in man

McMurray, J. , Seidelin, P. H., Howey, J. E.A., Balfour, D. J. and Struthers, A. D. (1988) The effect of atrial natriuretic factor on urinary albumin and β2-microglobulin excretion in man. Journal of Hypertension, 6(10), pp. 783-786.

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Abstract

The effect of a 20-min infusion of atrial natriuretic factor (ANF) 99-126, 0.4 jxg/kg per min, on both urinary albumin and [beta];2-microglobulin excretion was examined in nine normal male subjects during stable water diuresis. ANF caused a rise in urinary albumin in excretion (from 4.19 +/-; 0.66 to 13.49 +/-;3.07 ng/min, P < 0.01) without any significant change in either creatinine clearance of [beta];2-microglobulin excretion. These findings suggest that ANF may enhance glomerular permeability to albumin in man.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McMurray, Professor John
Authors: McMurray, J., Seidelin, P. H., Howey, J. E.A., Balfour, D. J., and Struthers, A. D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Journal of Hypertension
ISSN:0263-6352
ISSN (Online):1473-5598

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