Physiological increases in circulating noradrenaline are antinatriuretic in man

McMurray, J. J. , Seidelin, P. H., Balfour, D. J.K. and Struthers, A. D. (1988) Physiological increases in circulating noradrenaline are antinatriuretic in man. Journal of Hypertension, 6(9), pp. 757-761. (PMID:3183378)

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Low-dose (0.025 [micro]g/kg per min) noradrenaline infusion, resulting in a physiological plasma increment (280 pg/ml), was antinatriuretic in normal salt-replete male subjects. The reduction in sodium excretion (-20%, P<0.01) occurred without any change in the glomerular filtration rate but was associated with a significant (P<0.02) decline in lithium clearance. These results suggest that changes in circulating noradrenaline, within the physiological range, can decrease sodium excretion in man by enhancing proximal tubular sodium reabsorption. These findings extend previous investigations in man which used pharmacological doses of noradrenaline and are in agreement with animal evidence for a renal tubular antinatriuretic effect of the sympathetic nervous system.

Item Type:Articles
Glasgow Author(s) Enlighten ID:McMurray, Professor John
Authors: McMurray, J. J., Seidelin, P. H., Balfour, D. J.K., and Struthers, A. D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Journal of Hypertension
ISSN (Online):1473-5598

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