Genome maintenance in Trypanosomatids

Cabrera, G., Silva, V. G., Mendes, I. C., Machado, C. R. and McCulloch, R. (2017) Genome maintenance in Trypanosomatids. In: Santos da Silva, M. and Cano, M. I. N. (eds.) Molecular and Cellular Biology of Pathogenic Trypanosomatids. Series: Frontiers in parasitology, 1. Bentham Science, pp. 195-260. ISBN 9781681084060 (doi:10.2174/9781681084053117010008)

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The genome is the source of life, providing the information needed to direct all aspects of organismal function. Propagation of life requires copying of the genome and faithful transmission from parent to offspring. Many challenges confront genome propagation, including ensuring the accurate and complete copying of the DNA, circumventing impediments to DNA replication, and maintaining genome integrity in the face of myriad insults and during periods of cellular quiescence. Just as importantly, the genome must be allowed to change, either incrementally through small mutations in sequence or by large-scale rearrangements. Such changes not only drive evolution, but can be integral components of an organism’s life cycle. In this chapter we consider the rapidly growing body of knowledge on how the genomes of kinetoplastid parasites are maintained, by describing the range of genome repair and damage tolerance pathways that operate. We focus on Trypanosoma brucei, Trypanosoma cruzi and Leishmania, three important human and animal pathogens, but we believe the lessons learned from the study of genome maintenance in these genetically tractable parasites are applicable widely, not only to other parasites but throughout biology.

Item Type:Book Sections
Glasgow Author(s) Enlighten ID:Machado, Professor Carlos and Mendes, Ms Isabela and McCulloch, Professor Richard
Authors: Cabrera, G., Silva, V. G., Mendes, I. C., Machado, C. R., and McCulloch, R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Publisher:Bentham Science

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
515891Chromosomal recombination and repair in African trypanosomesRichard McCullochWellcome Trust (WELLCOME)089172/Z/09/ZIII - PARASITOLOGY
606431Kinase dependent control of DNA replication and repair as a drug target in Trypanosoma brucei.Richard McCullochBiotechnology and Biological Sciences Research Council (BBSRC)BB/K006495/1III - PARASITOLOGY
371799The Wellcome Centre for Molecular Parasitology ( Core Support )Andrew WatersWellcome Trust (WELLCOME)104111/Z/14/Z & AIII - PARASITOLOGY
68706114CONFAP Understanding diverged genome repair and replication functions in trypanosomatid parasitesRichard McCullochBiotechnology and Biological Sciences Research Council (BBSRC)BB/M028909/1III - PARASITOLOGY