Facile synthesis of polymer-peptide conjugates via direct amino acid coupling chemistry

Chimonides, G. F., Sohdi, A. A., Khaleghi, M. R., Hurley, C. R., Adams, D. J. and Topham, P. D. (2013) Facile synthesis of polymer-peptide conjugates via direct amino acid coupling chemistry. Journal of Polymer Science Part A: Polymer Chemistry, 51(22), pp. 4853-4859. (doi: 10.1002/pola.26913)

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Abstract

Polymer–peptide conjugates (also known as biohybrids) are attracting considerable attention as injectable materials owing to the self-assembling behavior of the peptide and the ability to control the material properties using the polymer component. To this end, a simple method for preparing poly(ethylene oxide)-oligophenylalanine polymer–peptide conjugates (mPEOm-Fn-OEt) using isobutylchloroformate as the activating reagent has been identified and developed. The synthetic approach reported employs an industrially viable route to produce conjugates with high yield and purity. Moreover, the approach allows judicious selection of the precursor building blocks to produce libraries of polymer–peptide conjugates with complete control over the molecular composition. Control over the molecular make-up of the conjugates allows fine control of the physicochemical properties, which will be exploited in future studies into the prominent self-assembling behavior of such materials.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Adams, Dave
Authors: Chimonides, G. F., Sohdi, A. A., Khaleghi, M. R., Hurley, C. R., Adams, D. J., and Topham, P. D.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Journal of Polymer Science Part A: Polymer Chemistry
Publisher:Wiley
ISSN:0887-624X
ISSN (Online):1099-0518
Published Online:16 September 2013

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