Raeburn, J., Mendoza-Cuenca, C., Cattoz, B. N., Little, M. A., Terry, A. E., Zamith Cardoso, A., Griffiths, P. C. and Adams, D. J. (2015) The effect of solvent choice on the gelation and final hydrogel properties of Fmoc–diphenylalanine. Soft Matter, 11(5), pp. 927-935. (doi: 10.1039/C4SM02256D)
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Abstract
Gels can be formed by dissolving Fmoc–diphenylalanine (Fmoc–PhePhe or FmocFF) in an organic solvent and adding water. We show here that the choice and amount of organic solvent allows the rheological properties of the gel to be tuned. The differences in properties arise from the microstructure of the fibre network formed. The organic solvent can then be removed post-gelation, without significant changes in the rheological properties. Gels formed using acetone are meta-stable and crystals of FmocFF suitable for X-ray diffraction can be collected from this gel.
| Item Type: | Articles |
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| Additional Information: | We thank the EPSRC for funding a studentship for JR. CMC acknowledges an Erasmus traineeship. Experiments at the ISIS Pulsed Neutron and Muon Source were supported by a beamtime allocation from the Science and Technology Facilities Council. We thank Diamond Light Source for access to beamline I19 (MT8728) that contributed to the results presented here. We would like to acknowledge the Liverpool CCI (Centre for Cell Imaging) for continuous support in this project. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Adams, Dave |
| Authors: | Raeburn, J., Mendoza-Cuenca, C., Cattoz, B. N., Little, M. A., Terry, A. E., Zamith Cardoso, A., Griffiths, P. C., and Adams, D. J. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Soft Matter |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1744-683X |
| ISSN (Online): | 1744-6848 |
| Published Online: | 08 December 2014 |
| Copyright Holders: | Copyright © 2015 The Royal Society of Chemistry |
| First Published: | First published in Soft Matter 11(5): 927-935 |
| Publisher Policy: | Reproduced under a Creative Commons license |
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