Triple-targeting Gram-negative selective antimicrobial peptides capable of disrupting the cell membrane and lipid A biosynthesis

Postma, T.M. and Liskamp, R.M.J. (2016) Triple-targeting Gram-negative selective antimicrobial peptides capable of disrupting the cell membrane and lipid A biosynthesis. RSC Advances, 6(70), pp. 65418-65421. (doi:10.1039/c6ra11550k)

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Abstract

Early lipid A biosynthesis is a potential antimicrobial target as this is an essential component of lipid A producing Gram-negative bacteria. Herein, we introduce a potent and highly synergistic Gram-negative selective triple-targeting antimicrobial peptide. The peptide contains a dual lipid A biosynthesis inhibiting sequence and an antimicrobial sequence.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert and Postma, Dr Tobias
Authors: Postma, T.M., and Liskamp, R.M.J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:RSC Advances
Publisher:Royal Society of Chemistry
ISSN:2046-2069
ISSN (Online):2046-2069
Published Online:04 July 2016
Copyright Holders:Copyright © 2016 Royal Society of Chemistry
First Published:First published in RSC Advances 6(70):65418-65421
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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