Polar hinges as functionalized conformational constraints in (bi)cyclic peptides

Van De Langemheen, H., Korotkovs, V., Bijl, J., Wilson, C. , Kale, S. S., Heinis, C. and Liskamp, R. M.J. (2017) Polar hinges as functionalized conformational constraints in (bi)cyclic peptides. ChemBioChem, 18(4), pp. 387-395. (doi:10.1002/cbic.201600612) (PMID:27982494)

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Abstract

Two polar hinges for cyclization of peptides have been developed, leading to bicyclic peptides and cyclized peptides with improved solubility and biological activity. Increasingly, we note that a good aqueous solubility of peptides is an absolute prerequisite, not only to allow handling and purification of our target peptides but also being crucial for biological activity characteristics. Compared to earlier hinges, the 1,1′,1“-(1,3,5-triazinane-1,3,5-triyl)tris(2-bromoethanone) (TATB) and 2,4,6-tris(bromomethyl)-s-triazine (TBMT), each containing three nitrogen atoms are structurally similar but chemically very different. Both were accessible in a one-step fashion from bromoacetonitrile. TATB and TBMT are very suitable for the preparation of more soluble bicyclic peptides. Azide-modified TATB and TBMT derivatives provide hinges for the preparation of cyclized peptides for incorporation on scaffolds to afford protein mimics.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert and Wilson, Dr Claire and Korotkovs, Mr Valerijs and Van De Langemheen, Mr Helmus
Authors: Van De Langemheen, H., Korotkovs, V., Bijl, J., Wilson, C., Kale, S. S., Heinis, C., and Liskamp, R. M.J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:ChemBioChem
Publisher:Wiley
ISSN:14394227
ISSN (Online):1439-7633
Published Online:16 December 2016

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