Protein export in malaria parasites: many membranes to cross

Marti, M. and Spielmann, T. (2013) Protein export in malaria parasites: many membranes to cross. Current Opinion in Microbiology, 16(4), pp. 445-451. (doi:10.1016/j.mib.2013.04.010) (PMID:23725671) (PMCID:PMC3755040)

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Abstract

The continuous multiplication of Plasmodium parasites in red blood cells leads to a rapid increase in parasite numbers and is responsible for the disease symptoms of malaria. Survival and virulence of the parasite are linked to parasite-induced changes of the host red blood cells. These alterations require export of a large number of parasite proteins that are trafficked across multiple membranes to reach the host cell. Two classes of exported proteins are known, those with a conserved Plasmodium export element (PEXEL/HT) or those without this motif (PNEPs). Recent work has revealed new aspects of the determinants required for export of these 2 protein classes, shedding new light on the mode of trafficking during the different transport steps en route to the host cell.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Marti, Professor Matthias
Authors: Marti, M., and Spielmann, T.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Current Opinion in Microbiology
Publisher:Elsevier
ISSN:1369-5274
ISSN (Online):1879-0364
Published Online:29 May 2013

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