Marti, M. and Spielmann, T. (2013) Protein export in malaria parasites: many membranes to cross. Current Opinion in Microbiology, 16(4), pp. 445-451. (doi: 10.1016/j.mib.2013.04.010) (PMID:23725671) (PMCID:PMC3755040)
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Abstract
The continuous multiplication of Plasmodium parasites in red blood cells leads to a rapid increase in parasite numbers and is responsible for the disease symptoms of malaria. Survival and virulence of the parasite are linked to parasite-induced changes of the host red blood cells. These alterations require export of a large number of parasite proteins that are trafficked across multiple membranes to reach the host cell. Two classes of exported proteins are known, those with a conserved Plasmodium export element (PEXEL/HT) or those without this motif (PNEPs). Recent work has revealed new aspects of the determinants required for export of these 2 protein classes, shedding new light on the mode of trafficking during the different transport steps en route to the host cell.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Marti, Professor Matthias |
| Authors: | Marti, M., and Spielmann, T. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Current Opinion in Microbiology |
| Publisher: | Elsevier |
| ISSN: | 1369-5274 |
| ISSN (Online): | 1879-0364 |
| Published Online: | 29 May 2013 |
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