Kearns, R., Macfarlane, A. , Grant, A., Puxty, K. , Harrison, P., Shaw, M., Anderson, K. and Kinsella, J. (2016) A randomised, controlled, double blind, non-inferiority trial of ultrasound-guided fascia iliaca block vs. spinal morphine for analgesia after primary hip arthroplasty. Anaesthesia, 71(12), pp. 1431-1440. (doi: 10.1111/anae.13620) (PMID:27714758)
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Abstract
We performed a single centre, double blind, randomised, controlled, non-inferiority study comparing ultrasound-guided fascia iliaca block with spinal morphine for the primary outcome of 24-h postoperative morphine consumption in patients undergoing primary total hip arthroplasty under spinal anaesthesia with levobupivacaine. One hundred and eight patients were randomly allocated to receive either ultrasound-guided fascia iliaca block with 2 mg.kg−1 levobupivacaine (fascia iliaca group) or spinal morphine 100 μg plus a sham ultrasound-guided fascia iliaca block using saline (spinal morphine group). The pre-defined non-inferiority margin was a median difference between the groups of 10 mg in cumulative intravenous morphine use in the first 24 h postoperatively. Patients in the fascia iliaca group received 25 mg more intravenous morphine than patients in the spinal morphine group (95% CI 9.0–30.5 mg, p < 0.001). Ultrasound-guided fascia iliaca block was significantly worse than spinal morphine in the provision of analgesia in the first 24 h after total hip arthroplasty. No increase in side-effects was noted in the spinal morphine group but the study was not powered to investigate all secondary outcomes.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Kearns, Dr Rachel and Kinsella, Professor John and Grant, Dr Andrew and MacFarlane, Dr Alan and Shaw, Dr Martin and Puxty, Dr Kathryn and Harrison, Dr Paul |
Authors: | Kearns, R., Macfarlane, A., Grant, A., Puxty, K., Harrison, P., Shaw, M., Anderson, K., and Kinsella, J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
Journal Name: | Anaesthesia |
Publisher: | Wiley |
ISSN: | 0003-2409 |
ISSN (Online): | 1365-2044 |
Published Online: | 07 October 2016 |
Copyright Holders: | Copyright © 2016 Wiley |
First Published: | First published in Anaesthesia 71(12):1431-1440 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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