Conserved fever pathways across vertebrates: a herpesvirus expressed decoy TNF-α receptor delays behavioral fever in fish

Rakus, K. et al. (2017) Conserved fever pathways across vertebrates: a herpesvirus expressed decoy TNF-α receptor delays behavioral fever in fish. Cell Host and Microbe, 21(2), pp. 244-253. (doi:10.1016/j.chom.2017.01.010) (PMID:28182952) (PMCID:PMC5301049)

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Abstract

Both endotherms and ectotherms (e.g., fish) increase their body temperature to limit pathogen infection. Ectotherms do so by moving to warmer places, hence the term “behavioral fever.” We studied the manifestation of behavioral fever in the common carp infected by cyprinid herpesvirus 3, a native carp pathogen. Carp maintained at 24°C died from the infection, whereas those housed in multi-chamber tanks encompassing a 24°C–32°C gradient migrated transiently to the warmest compartment and survived as a consequence. Behavioral fever manifested only at advanced stages of infection. Consistent with this, expression of CyHV-3 ORF12, encoding a soluble decoy receptor for TNF-α, delayed the manifestation of behavioral fever and promoted CyHV-3 replication in the context of a temperature gradient. Injection of anti-TNF-α neutralizing antibodies suppressed behavioral fever, and decreased fish survival in response to infection. This study provides a unique example of how viruses have evolved to alter host behavior to increase fitness.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gatherer, Dr Derek and Davison, Professor Andrew
Authors: Rakus, K., Ronsmans, M., Forlenza, M., Boutier, M., Piazzon, M. C., Jazowiecka-Rakus, J., Gatherer, D., Athanasiadis, A., Farnir, F., Davison, A. J., Boudinot, P., Michiels, T., Wiegertjes, G. F., and Vanderplasschen, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Cell Host and Microbe
Publisher:Elsevier
ISSN:1931-3128
ISSN (Online):1934-6069
Published Online:08 February 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Cell Host and Microbe 21(2):244-253
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
656321Genomics of human cytomegalovirusAndrew DavisonMedical Research Council (MRC)MC_UU_12014/3MVLS III - CENTRE FOR VIRUS RESEARCH