Clonal outbreak of Plasmodium falciparum infection in Eastern Panama

Obaldia, N. et al. (2015) Clonal outbreak of Plasmodium falciparum infection in Eastern Panama. Journal of Infectious Diseases, 211(7), pp. 1087-1096. (doi:10.1093/infdis/jiu575) (PMID:25336725) (PMCID:PMC4366603)

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Abstract

Identifying the source of resurgent parasites is paramount to a strategic, successful intervention for malaria elimination. Although the malaria incidence in Panama is low, a recent outbreak resulted in a 6-fold increase in reported cases. We hypothesized that parasites sampled from this epidemic might be related and exhibit a clonal population structure. We tested the genetic relatedness of parasites, using informative single-nucleotide polymorphisms and drug resistance loci. We found that parasites were clustered into 3 clonal subpopulations and were related to parasites from Colombia. Two clusters of Panamanian parasites shared identical drug resistance haplotypes, and all clusters shared a chloroquine-resistance genotype matching the pfcrt haplotype of Colombian origin. Our findings suggest these resurgent parasite populations are highly clonal and that the high clonality likely resulted from epidemic expansion of imported or vestigial cases. Malaria outbreak investigations that use genetic tools can illuminate potential sources of epidemic malaria and guide strategies to prevent further resurgence in areas where malaria has been eliminated.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Marti, Professor Matthias
Authors: Obaldia, N., Baro, N. K., Calzada, J. E., Santamaria, A. M., Daniels, R., Wong, W., Chang, H.-H., Hamilton, E. J., Arevalo-Herrera, M., Herrera, S., Wirth, D. F., Hartl, D. L., Marti, M., and Volkman, S. K.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Infectious Diseases
Publisher:Oxford University Press
ISSN:0022-1899
ISSN (Online):1537-6613
Published Online:21 October 2014

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