Choi, J.-Y., Duraisingh, M. T., Marti, M. , Ben Mamoun, C. and Voelker, D. R. (2015) From protease to decarboxylase: the molecular metamorphosis of phosphatidylserine decarboxylase. Journal of Biological Chemistry, 290(17), pp. 10972-10980. (doi: 10.1074/jbc.M115.642413) (PMID:25724650) (PMCID:PMC4409258)
|
Text
135135.pdf - Published Version 1MB |
Abstract
Background: Phosphatidylserine decarboxylase (PSD) undergoes an autoendoproteolytic cleavage but the mechanism has not been defined.
Results: PSD proenzyme processing occurs by a canonical serine protease mechanism catalyzed by a conserved aspartate-histidine-serine triad. Conclusion: PSD proenzyme executes a proteolytic reaction in cis that creates the active site of the decarboxylase. Significance: The mechanism of autoendoproteolyic processing of PSDs across phyla has been elucidated.| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Marti, Professor Matthias |
| Authors: | Choi, J.-Y., Duraisingh, M. T., Marti, M., Ben Mamoun, C., and Voelker, D. R. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Journal of Biological Chemistry |
| Publisher: | American Society for Biochemistry and Molecular Biology |
| ISSN: | 0021-9258 |
| ISSN (Online): | 1083-351X |
| Published Online: | 26 February 2015 |
| Copyright Holders: | Copyright © 2015 The American Society for Biochemistry and Molecular Biology, Inc. |
| First Published: | First published in Journal of Biological Chemistry 290(17):10972-10980 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
Deposit and Record Details