Shared elements of host-targeting pathways among apicomplexan parasites of differing lifestyles

Pellé, K. G., Jiang, R. H. Y., Mantel, P.-Y., Xiao, Y.-P., Hjelmqvist, D., Gallego-Lopez, G. M., O.T. Lau, A., Kang, B.-H., Allred, D. R. and Marti, M. (2015) Shared elements of host-targeting pathways among apicomplexan parasites of differing lifestyles. Cellular Microbiology, 17(11), pp. 1618-1639. (doi:10.1111/cmi.12460) (PMID:25996544)

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Abstract

Apicomplexans are a diverse group of obligate parasites occupying different intracellular niches that require modification to meet the needs of the parasite. To efficiently manipulate their environment, apicomplexans translocate numerous parasite proteins into the host cell. Whereas some parasites remain contained within a parasitophorous vacuole membrane (PVM) throughout their developmental cycle, others do not, a difference that affects the machinery needed for protein export. A signal-mediated pathway for protein export into the host cell has been characterized in Plasmodium parasites, which maintain the PVM. Here, we functionally demonstrate an analogous host-targeting pathway involving organellar staging prior to secretion in the related bovine parasite, Babesia bovis, a parasite that destroys the PVM shortly after invasion. Taking into account recent identification of a similar signal-mediated pathway in the coccidian parasite Toxoplasma gondii, we suggest a model in which this conserved pathway has evolved in multiple steps from signal-mediated trafficking to specific secretory organelles for controlled secretion to a complex protein translocation process across the PVM.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Marti, Professor Matthias
Authors: Pellé, K. G., Jiang, R. H. Y., Mantel, P.-Y., Xiao, Y.-P., Hjelmqvist, D., Gallego-Lopez, G. M., O.T. Lau, A., Kang, B.-H., Allred, D. R., and Marti, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Cellular Microbiology
Publisher:Wiley
ISSN:1462-5814
ISSN (Online):1462-5822
Published Online:21 May 2015

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