Synthesis of six mexiletine derivatives with isoindolines attached as potential antioxidants and their evaluation as cardioprotective agents

Chau, B. A., Drummond, G., Jackson, W. R., Jarrott, B., Miller, A. A. , Subasinghe, K. R., Tan, C. Y.R., White, P. J., Wright, C. E. and Ziogas, J. (2015) Synthesis of six mexiletine derivatives with isoindolines attached as potential antioxidants and their evaluation as cardioprotective agents. MedChemComm, 6(4), pp. 634-639. (doi: 10.1039/C4MD00459K)

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Abstract

Six derivatives containing mexiletine and its 2,6-dichloro analogue to which the potential antioxidant moiety isoindoline, its N-oxide and the N-hydroxy derivatives have been attached, have been evaluated as cardioprotective agents. Four of the derivatives at different oxidation states, NH, NO and NOH had significant cardioprotective properties in an in vitro ischaemia model. In contrast to previous reports the NH compounds were not the most active.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Miller, Dr Alyson
Authors: Chau, B. A., Drummond, G., Jackson, W. R., Jarrott, B., Miller, A. A., Subasinghe, K. R., Tan, C. Y.R., White, P. J., Wright, C. E., and Ziogas, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:MedChemComm
Publisher:Royal Society of Chemistry
ISSN:2040-2503
ISSN (Online):2040-2511
Published Online:15 December 2014

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