Chau, B. A., Drummond, G., Jackson, W. R., Jarrott, B., Miller, A. A. , Subasinghe, K. R., Tan, C. Y.R., White, P. J., Wright, C. E. and Ziogas, J. (2015) Synthesis of six mexiletine derivatives with isoindolines attached as potential antioxidants and their evaluation as cardioprotective agents. MedChemComm, 6(4), pp. 634-639. (doi: 10.1039/C4MD00459K)
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Abstract
Six derivatives containing mexiletine and its 2,6-dichloro analogue to which the potential antioxidant moiety isoindoline, its N-oxide and the N-hydroxy derivatives have been attached, have been evaluated as cardioprotective agents. Four of the derivatives at different oxidation states, NH, NO and NOH had significant cardioprotective properties in an in vitro ischaemia model. In contrast to previous reports the NH compounds were not the most active.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Miller, Dr Alyson |
| Authors: | Chau, B. A., Drummond, G., Jackson, W. R., Jarrott, B., Miller, A. A., Subasinghe, K. R., Tan, C. Y.R., White, P. J., Wright, C. E., and Ziogas, J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | MedChemComm |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 2040-2503 |
| ISSN (Online): | 2040-2511 |
| Published Online: | 15 December 2014 |
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