Parasite excretory-secretory products and their effects on metabolic syndrome

Crowe, J., Lumb, F.E., Harnett, M.M. and Harnett, W. (2017) Parasite excretory-secretory products and their effects on metabolic syndrome. Parasite Immunology, 39(5), e12410. (doi:10.1111/pim.12410) (PMID:28066896)

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Abstract

Obesity, one of the main causes of metabolic syndrome (MetS), is an increasingly common health and economic problem worldwide, and one of the major risk factors for developing type 2 diabetes and cardiovascular disease. Chronic, low-grade inflammation is associated with MetS and obesity. A dominant type 2/anti-inflammatory response is required for metabolic homeostasis within adipose tissue: during obesity, this response is replaced by infiltrating, inflammatory macrophages and T cells. Helminths and certain protozoan parasites are able to manipulate the host immune response towards a TH2 immune phenotype that is beneficial for their survival and there is emerging data that there is an inverse correlation between the incidence of MetS and helminth infections, suggesting that, as with autoimmune and allergic diseases, helminths may play a protective role against MetS disease. Within this review, we will focus primarily on the excretory-secretory products that the parasites produce to modulate the immune system and discuss their potential use as therapeutics against MetS and its associated pathologies.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Harnett, Professor Margaret and Lumb, Miss Felicity and Crowe, Dr Jenny and Harnett, Professor William
Authors: Crowe, J., Lumb, F.E., Harnett, M.M., and Harnett, W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Parasite Immunology
Publisher:Wiley
ISSN:0141-9838
ISSN (Online):1365-3024
Published Online:09 January 2017
Copyright Holders:Copyright © 2017 John Wiley and Sons Ltd
First Published:First published in Parasite immunology 39(5):e12410
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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