Frog foams and natural protein surfactants

Cooper, A., Vance, S. J., Smith, B. O. and Kennedy, M. W. (2017) Frog foams and natural protein surfactants. Colloids and Surfaces A: Physicochemical and Engineering Aspects, (doi:10.1016/j.colsurfa.2017.01.049) (Early Online Publication)

[img]
Preview
Text
134530.pdf - Accepted Version
Available under License Creative Commons Attribution.

5MB

Abstract

Foams and surfactants are relatively rare in biology because of their potential to harm cell membranes and other delicate tissues. However, in recent work we have identified and characterized a number of natural surfactant proteins found in the foam nests of tropical frogs and other unusual sources. These proteins, and their associated foams, are relatively stable and bio-compatible, but with intriguing molecular structures that reveal a new class of surfactant activity. Here we review the structures and functional mechanisms of some of these proteins as revealed by experiments involving a range of biophysical and biochemical techniques, with additional mechanistic support coming from more recent site-directed mutagenesis studies.

Item Type:Articles
Status:Early Online Publication
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kennedy, Professor Malcolm and Smith, Dr Brian and Cooper, Professor Alan
Authors: Cooper, A., Vance, S. J., Smith, B. O., and Kennedy, M. W.
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
College of Science and Engineering > School of Chemistry
Journal Name:Colloids and Surfaces A: Physicochemical and Engineering Aspects
Publisher:Elsevier
ISSN:0927-7757
ISSN (Online):1873-4359|
Published Online:21 January 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2017
Publisher Policy:Reproduced under a creative commons license

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
350081Latherin - a natural surfactant protein for biomedical and environmental applicationsMalcolm KennedyWellcome Trust (WELLCOME)070994/Z/03/ZLS - ANIMAL BIOLOGY