Cooper, A., Vance, S. J., Smith, B. O. and Kennedy, M. W. (2017) Frog foams and natural protein surfactants. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 534, pp. 120-129. (doi: 10.1016/j.colsurfa.2017.01.049) (PMID:29276339) (PMCID:PMC5727673)
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Abstract
Foams and surfactants are relatively rare in biology because of their potential to harm cell membranes and other delicate tissues. However, in recent work we have identified and characterized a number of natural surfactant proteins found in the foam nests of tropical frogs and other unusual sources. These proteins, and their associated foams, are relatively stable and bio-compatible, but with intriguing molecular structures that reveal a new class of surfactant activity. Here we review the structures and functional mechanisms of some of these proteins as revealed by experiments involving a range of biophysical and biochemical techniques, with additional mechanistic support coming from more recent site-directed mutagenesis studies.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Kennedy, Professor Malcolm and Smith, Dr Brian and Cooper, Professor Alan |
| Authors: | Cooper, A., Vance, S. J., Smith, B. O., and Kennedy, M. W. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Life Sciences College of Science and Engineering > School of Chemistry |
| Journal Name: | Colloids and Surfaces A: Physicochemical and Engineering Aspects |
| Publisher: | Elsevier |
| ISSN: | 0927-7757 |
| ISSN (Online): | 1873-4359 |
| Published Online: | 21 January 2017 |
| Copyright Holders: | Copyright © 2017 The Authors |
| First Published: | First published in Colloids and Surfaces A: Physicochemical and Engineering Aspects 534:120-129 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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