Frederickson, M., Roszak, A. W., Coggins, J. R., Lapthorn, A. J. and Abell, C. (2004) (1R,4S,5R)-3-Fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases. Organic and Biomolecular Chemistry, 2(11), pp. 1592-1596. (doi: 10.1039/B404535A)
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Abstract
The fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases has been prepared from naturally occuring (−)-quinic acid over seven steps and has been shown to be the most potent inhibitor reported to date of the type II enzyme from Mycobacterium tuberculosis.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Lapthorn, Dr Adrian and Abell, Dr Chris and Coggins, Professor John |
Authors: | Frederickson, M., Roszak, A. W., Coggins, J. R., Lapthorn, A. J., and Abell, C. |
College/School: | College of Medical Veterinary and Life Sciences > School of Life Sciences College of Science and Engineering > School of Chemistry |
Journal Name: | Organic and Biomolecular Chemistry |
Publisher: | Royal Society of Chemistry |
ISSN: | 1477-0520 |
ISSN (Online): | 1477-0539 |
Published Online: | 06 May 2004 |
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