Chenery, A. L., Antignano, F., Burrows, K., Scheer, S., Perona-Wright, G. and Zaph, C. (2016) Low-dose intestinal Trichuris muris infection alters the lung immune microenvironment and can suppress allergic airway inflammation. Infection and Immunity, 84(2), pp. 491-501. (doi: 10.1128/IAI.01240-15) (PMID:26644379) (PMCID:PMC4730564)
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Abstract
Immunological cross talk between mucosal tissues such as the intestine and the lung is poorly defined during homeostasis and disease. Here, we show that a low-dose infection with the intestinally restricted helminth parasite Trichuris muris results in the production of Th1 cell-dependent gamma interferon (IFN-γ) and myeloid cell-derived interleukin-10 (IL-10) in the lung without causing overt airway pathology. This cross-mucosal immune response in the lung inhibits the development of papain-induced allergic airway inflammation, an innate cell-mediated type 2 airway inflammatory disease. Thus, we identify convergent and nonredundant roles of adaptive and innate immunity in mediating cross-mucosal suppression of type 2 airway inflammation during low-dose helminth-induced intestinal inflammation. These results provide further insight in identifying novel intersecting immune pathways elicited by gut-to-lung mucosal cross talk.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Perona-Wright, Dr Georgia |
Authors: | Chenery, A. L., Antignano, F., Burrows, K., Scheer, S., Perona-Wright, G., and Zaph, C. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Infection and Immunity |
Publisher: | American Society for Microbiology |
ISSN: | 0019-9567 |
ISSN (Online): | 1098-5522 |
Published Online: | 07 December 2015 |
Copyright Holders: | Copyright © 2016 Chenery et al. |
First Published: | First published in Infection and Immunity 84(2):491-501 |
Publisher Policy: | Reproduced under a Creative Commons License |
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