Low-dose intestinal Trichuris muris infection alters the lung immune microenvironment and can suppress allergic airway inflammation

Chenery, A. L., Antignano, F., Burrows, K., Scheer, S., Perona-Wright, G. and Zaph, C. (2016) Low-dose intestinal Trichuris muris infection alters the lung immune microenvironment and can suppress allergic airway inflammation. Infection and Immunity, 84(2), pp. 491-501. (doi: 10.1128/IAI.01240-15) (PMID:26644379) (PMCID:PMC4730564)

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Abstract

Immunological cross talk between mucosal tissues such as the intestine and the lung is poorly defined during homeostasis and disease. Here, we show that a low-dose infection with the intestinally restricted helminth parasite Trichuris muris results in the production of Th1 cell-dependent gamma interferon (IFN-γ) and myeloid cell-derived interleukin-10 (IL-10) in the lung without causing overt airway pathology. This cross-mucosal immune response in the lung inhibits the development of papain-induced allergic airway inflammation, an innate cell-mediated type 2 airway inflammatory disease. Thus, we identify convergent and nonredundant roles of adaptive and innate immunity in mediating cross-mucosal suppression of type 2 airway inflammation during low-dose helminth-induced intestinal inflammation. These results provide further insight in identifying novel intersecting immune pathways elicited by gut-to-lung mucosal cross talk.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Perona-Wright, Dr Georgia
Authors: Chenery, A. L., Antignano, F., Burrows, K., Scheer, S., Perona-Wright, G., and Zaph, C.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Infection and Immunity
Publisher:American Society for Microbiology
ISSN:0019-9567
ISSN (Online):1098-5522
Published Online:07 December 2015
Copyright Holders:Copyright © 2016 Chenery et al.
First Published:First published in Infection and Immunity 84(2):491-501
Publisher Policy:Reproduced under a Creative Commons License

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