A retrospective cohort study of the influence of lifestyle factors on survival of patients undergoing surgery for colorectal cancer.

Alexander, D., Allardice, G. M., Moug, S. J. and Morrison, D. S. (2017) A retrospective cohort study of the influence of lifestyle factors on survival of patients undergoing surgery for colorectal cancer. Colorectal Disease, 19(6), pp. 544-550. (doi: 10.1111/codi.13594) (PMID:28027419)

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Abstract

Aim: Several modifiable and non-modifiable health related behaviours are associated with the incidence of Colorectal Cancer (CRC), but there is little research on their association with survival. The project aimed to investigate possible relationships between modifiable behavioural factors and outcomes on a study cohort of CRC patients undergoing potentially curative surgery. Method: A retrospective cohort study was carried out of patients diagnosed with non-metastatic CRC undergoing elective curative surgery (January 2011 - December 2012), residing in the NHS Greater Glasgow & Clyde (NHSGGC) area, UK. Data were obtained from the Scottish Cancer Registry, National Scottish Death Records. Pre-operative assessment of smoking, alcohol consumption, nurse-measured body mass index (BMI) and exercise levels were recorded and patients were followed until death or censorship. Survival analysis was carried out and proportional hazards assumptions were assessed graphically using plots and were then formally tested using the PHTEST procedure in STATA. Results: Of the initial 527 patients, 181 (34%) satisfied the inclusion criteria. The total duration of follow up was 480 person-years. At the pre-operative assessment, 75% were overweight or obese, 10.6% were current smokers, 13.1% recorded excess alcohol consumption and 8.5% had physical difficulty climbing stairs. Age, BMI, histopathological stage and physical capacity all independently affected survival (P<0.05). Overweight patients (HR 2.81) and those who had difficulty climbing stairs (HR 3.31) had a significantly poorer survival. Conclusion: The study found evidence that pre-operative exercise capacity and BMI are important independent prognostic factors of survival in patients undergoing curative surgery for CRC.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Moug, Ms Susan and Morrison, Dr David and Allardice, Dr Gwen
Authors: Alexander, D., Allardice, G. M., Moug, S. J., and Morrison, D. S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Colorectal Disease
Publisher:Wiley
ISSN:1462-8910
ISSN (Online):1463-1318
Published Online:27 December 2016
Copyright Holders:Copyright © 2016 The Association of Coloproctology of Great Britain and Ireland
First Published:First published in Colorectal Disease 19(6): 544-550
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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