New concepts in compartmental modelling

Lindsay, A.E., Lindsay, K.A. and Rosenberg, J.R. (2007) New concepts in compartmental modelling. Computing and Visualization in Science, 10(2), pp. 79-98. (doi: 10.1007/s00791-006-0035-8)

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Continuum and compartmental models are presented as alternative descriptions of the electrical behaviour of a dendrite. The one-dimensional continuum model provides a reference against which the accuracy of compartmental models may be assessed. Traditional compartmental models are shown to be first- and not second-order accurate in the presence of synaptic input contrary to what is often claimed. This reduced accuracy arises from the inability of a traditional model to accurately locate synaptic input. A compartment defined by two potentials is introduced to describe a dendritic section, and the influence of synaptic input to the section is divided between its boundaries by means of a partitioning rule. The new compartmental model, with the same level of discretisation as a traditional model, is an order of magnitude more accurate and precise than traditional compartmental models in the presence of synaptic input. Consequently, the new model provides a more powerful tool for distinguishing between different models of an experiment than is possible using a traditional compartmental model.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Rosenberg, Prof Jay and Lindsay, Professor Kenneth
Authors: Lindsay, A.E., Lindsay, K.A., and Rosenberg, J.R.
Subjects:R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Q Science > QA Mathematics
College/School:College of Science and Engineering > School of Mathematics and Statistics > Mathematics
Journal Name:Computing and Visualization in Science
ISSN (Online):1433-0369
Published Online:17 November 2006

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