Role of IL-33 and ST2 signalling pathway in multiple sclerosis: expression by oligodendrocytes and inhibition of myelination in central nervous system

Allan, D., Fairlie-Clarke, K. J., Elliott, C. , Schuh, C., Barnett, S. C. , Lassmann, H., Linnington, C. and Jiang, H.-R. (2016) Role of IL-33 and ST2 signalling pathway in multiple sclerosis: expression by oligodendrocytes and inhibition of myelination in central nervous system. Acta Neuropathologica Communications, 4(1), 75. (doi:10.1186/s40478-016-0344-1) (PMID:27455844) (PMCID:PMC4960877)

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Abstract

Recent research findings have provided convincing evidence indicating a role for Interleukin-33 (IL-33) signalling pathway in a number of central nervous system (CNS) diseases including multiple sclerosis (MS) and Alzheimer’s disease. However, the exact function of IL-33 molecule within the CNS under normal and pathological conditions is currently unknown. In this study, we have mapped cellular expression of IL-33 and its receptor ST2 by immunohistochemistry in the brain tissues of MS patients and appropriate controls; and investigated the functional significance of these findings in vitro using a myelinating culture system. Our results demonstrate that IL-33 is expressed by neurons, astrocytes and microglia as well as oligodendrocytes, while ST2 is expressed in the lesions by oligodendrocytes and within and around axons. Furthermore, the expression levels and patterns of IL-33 and ST2 in the lesions of acute and chronic MS patient brain samples are enhanced compared with the healthy brain tissues. Finally, our data using rat myelinating co-cultures suggest that IL-33 may play an important role in MS development by inhibiting CNS myelination.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Linington, Professor Christopher and Jiang, Dr Hui-Rong and Elliott, Dr Christina and Fairlie-Clarke, Dr Karen and Schuh, Ms Cornelia and Allan, Miss Debbie and Barnett, Professor Susan
Authors: Allan, D., Fairlie-Clarke, K. J., Elliott, C., Schuh, C., Barnett, S. C., Lassmann, H., Linnington, C., and Jiang, H.-R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Acta Neuropathologica Communications
Publisher:BioMed Central
ISSN:2051-5960
ISSN (Online):2051-5960
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Acta Neuropathologica Communications 4(1):75
Publisher Policy:Reproduced under a Creative Commons License

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