Systemic T cells and monocyte characteristics in patients with denture stomatitis

Maciąg, J. et al. (2017) Systemic T cells and monocyte characteristics in patients with denture stomatitis. Journal of Prosthodontics, 26(1), pp. 19-28. (doi: 10.1111/jopr.12447) (PMID:26883670)

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Abstract

Purpose: Chronic inflammatory disorders of the oral cavity, such as periodontitis, were recently linked to systemic immune activation. Since fungal oral infections have not yet been studied in this respect, the aim of our study is to determine whether the local inflammation caused by oral fungal infection of the palatal tissue (denture stomatitis—DS) is associated with the systemic inflammatory response. This question is becoming essential as the population ages. Materials and Methods: Peripheral blood of DS patients (n = 20) and control patients (n = 24) was assessed with flow cytometry to determine lymphocyte and monocyte profiles. Intracellular cytometric analysis was carried out to establish cytokine production by T cells. DS was diagnosed based on clinical symptoms of DS such as swelling and redness of oral mucosa, confirmed by microbiological swabs for fungal colonization with Candida species. The control group was recruited from denture users without clinical and microbiological signs of oral infections. Results: Percentages of peripheral lymphocytes, T cells, monocytes, and their subpopulations were similar in both studied groups. The exception was median percentages of CD25+ T cell subsets, which were significantly lower in DS patients than in control subjects. This reduction was observed in both CD4 T cell subset (16.7% and 28.1%; p = 0.0006) and CD8 T cell subset (4.6% and 7.0%; p = 0.007) Conclusions: While DS and associated local fungal infection do not overtly affect activation of monocytes or lymphocytes, the number of CD 25+ T cells is significantly lower in the DS patients, possibly indicating limited potential for the infection clearance in denture-using aging patients.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Czesnikiewicz-Guzik, Dr Marta and Guzik, Professor Tomasz
Authors: Maciąg, J., Mikołajczyk, T., Matusik, P., Nosalski, R., Sagan, A., Maciąg, A., Nowakowski, D., Wilk, G., Osmenda, G., Guzik, T., and Cześnikiewicz-Guzik, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Journal of Prosthodontics
Publisher:Wiley
ISSN:1059-941X
ISSN (Online):1532-849X
Published Online:16 February 2016
Copyright Holders:Copyright © 2016 Wiley
First Published:First published in Journal of Prosthodontics 26(1):19-28
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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