The effect of the treatment of denture related stomatitis on peripheral T cells and monocytes

Maciag, J., Mikolajczyk, T., Matusik, P., Nowakowski, D., Robertson, D. , Maciag, A., Osmenda, G. and Czesnikiewicz-Guzik, M. (2017) The effect of the treatment of denture related stomatitis on peripheral T cells and monocytes. Oral Health and Preventive Dentistry, 15(3), pp. 259-268. (doi: 10.3290/j.ohpd.a38527) (PMID:28674706)

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Abstract

Purpose: Systemic immune activation has been recently linked to chronic inflammatory disorders of the oral cavity, particularly to periodontitis. The purpose of this study was to determine whether treatment of a fungus-induced oral inflammation, namely denture-related stomatitis (DRS), can affect the activation of the systemic immune response. Materials and Methods: Peripheral blood from patients with denture-related stomatitis caused by Candida albicans infection (n = 15) was collected at three time points: before treatment with nystatin, at the end of therapy and 2 months after finishing therapy. Activation of T cells and monocytes was assessed by flow cytometry. Results: The percentages of peripheral lymphocytes, T cells and their subpopulations, as well as monocytes were similar before, immediately following and two months after nystatin treatment. Cells expressing early activation marker CD69 and RANTES C-C chemokine receptor type 5 significantly increased immediately after treatment and returned to baseline levels after two months. Th17 cells, which have been implicated in the pathogenesis of DRS, remained unchanged. Central memory CD4+ subset and intermediate subset of monocytes were lower after therapy and this effect was sustained for two months. Conclusion: Treatment of denture-related stomatitis does not seem to affect the general state of the cellular components of the immune system. The results suggest a potential proinflammatory effect of the antifungal agent, nystatin. Although transient and not intense, this effect might be of particular clinical importance, because of relationships between inflammation and certain diseases. Further studies are required to clarify this aspect.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mikolajczyk, Dr Tomasz and Robertson, Mr Douglas and Czesnikiewicz-Guzik, Dr Marta and Maciag, Miss Joanna
Authors: Maciag, J., Mikolajczyk, T., Matusik, P., Nowakowski, D., Robertson, D., Maciag, A., Osmenda, G., and Czesnikiewicz-Guzik, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Oral Health and Preventive Dentistry
Publisher:Quintessence Publishing
ISSN:1602-1622
ISSN (Online):1757-9996
Copyright Holders:Copyright © 2017 Quintessence Publishing Group
First Published:First published in Oral Health and Preventive Dentistry 15(3): 259-268
Publisher Policy:Reproduced with the permission of the Editor

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