3D-printed devices for continuous-flow organic chemistry

Dragone, V., Sans, V., Rosnes, M. H., Kitson, P. J. and Cronin, L. (2013) 3D-printed devices for continuous-flow organic chemistry. Beilstein Journal of Organic Chemistry, 9, pp. 951-959. (doi: 10.3762/bjoc.9.109) (PMID:23766811) (PMCID:PMC3678713)

Abstract

We present a study in which the versatility of 3D-printing is combined with the processing advantages of flow chemistry for the synthesis of organic compounds. Robust and inexpensive 3D-printed reactionware devices are easily connected using standard fittings resulting in complex, custom-made flow systems, including multiple reactors in a series with in-line, real-time analysis using an ATR-IR flow cell. As a proof of concept, we utilized two types of organic reactions, imine syntheses and imine reductions, to show how different reactor configurations and substrates give different products.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Kitson, Dr Philip and Rosnes, Dr Mali and Cronin, Professor Lee and Sans Sangorrin, Dr Victor
• Authors: Dragone, V., Sans, V., Rosnes, M. H., Kitson, P. J., and Cronin, L.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Beilstein Journal of Organic Chemistry
• Publisher: Beilstein-Institut
• ISSN: 1860-5397
• ISSN (Online): 1860-5397
• Copyright Holders: Copyright © 2013 Dragone et al.
• First Published: First published in Beilstein Journal of Organic Chemistry 9:951-959
• Publisher Policy: Reproduced under a creative commons license