Heart rate: a prognostic factor and therapeutic target in chronic heart failure. The distinct roles of drugs with heart rate-lowering properties

Dobre, D. et al. (2014) Heart rate: a prognostic factor and therapeutic target in chronic heart failure. The distinct roles of drugs with heart rate-lowering properties. European Journal of Heart Failure, 16(1), pp. 76-85. (doi:10.1093/eurjhf/hft129) (PMID:23928650)

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Abstract

Heart rate not only predicts outcome but may also be a therapeutic target in patients with chronic heart failure. Several classes of pharmacological agents can be used to modulate heart rate, including beta-blockers, ivabradine, digoxin, amiodarone, and verapamil. Choice of agent will depend on heart rhythm, co-morbidities, and disease phenotype. Beneficial and harmful interactions may also exist. The aim of this paper is to summarize the current body of knowledge regarding the relevance of heart rate as a prognostic factor (risk marker) and particularly as a therapeutic target (risk factor) in patients with chronic heart failure, with a special focus on ivabradine, a novel agent that is currently the only available purely bradycardic agent.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cleland, Professor John
Authors: Dobre, D., Borer, J. S., Fox, K., Swedberg, K., Adams, K. F., Cleland, J. G.F., Cohen-Solal, A., Gheorghiade, M., Gueyffier, F., O'Connor, C. M., Fiuzat, M., Patak, A., Piña, I. L., Rosano, G., Sabbah, H. N., Tavazzi, L., and Zannad, F.
Subjects:R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
Journal Name:European Journal of Heart Failure
ISSN:1388-9842
ISSN (Online):1879-0844
Published Online:03 December 2013

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