Role of cysteine residues and disulfide bonds in the activity of a legume root nodule-specific, cysteine-rich peptide

Haag, A. F. , Kerscher, B., Dall'Angelo, S., Sani, M., Longhi, R., Baloban, M., Wilson, H. M., Mergaert, P., Zanda, M. and Ferguson, G. P. (2012) Role of cysteine residues and disulfide bonds in the activity of a legume root nodule-specific, cysteine-rich peptide. Journal of Biological Chemistry, 287(14), pp. 10791-10798. (doi: 10.1074/jbc.M111.311316) (PMID:22351783) (PMCID:PMC3322895)

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Abstract

Background: Legume antimicrobial peptides (AMPs) mediate Sinorhizobium meliloti bacteroid differentiation. Results: Cysteine replacements and disulfide bond modifications influence the antimicrobial activity of a legume AMP and its ability to mediate S. meliloti bacteroid differentiation. Conclusion: Specific changes to legume AMPs influence their activity against S. meliloti. Significance: Understanding the relationship of AMPs in S. meliloti bacteroid differentiation is fundamental for nitrogen fixation and legume growth.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Haag, Dr Andreas
Authors: Haag, A. F., Kerscher, B., Dall'Angelo, S., Sani, M., Longhi, R., Baloban, M., Wilson, H. M., Mergaert, P., Zanda, M., and Ferguson, G. P.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Journal of Biological Chemistry
Publisher:American Society for Biochemistry and Molecular Biology
ISSN:0021-9258
ISSN (Online):1083-351X
Published Online:17 February 2012

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