The long-term prognostic significance of 6-minute walk test distance in patients with chronic heart failure

Ingle, L., Cleland, J. G. and Clark, A. L. (2014) The long-term prognostic significance of 6-minute walk test distance in patients with chronic heart failure. BioMed Research International, 2014, 505969. (doi: 10.1155/2014/505969) (PMID:24800236) (PMCID:PMC3985138)

Abstract

Background. The 6-minute walk test (6-MWT) is used to assess patients with chronic heart failure (CHF). The prognostic significance of the 6-MWT distance during long-term followup (>5 years) is unclear. Methods. 1,667 patients (median [inter-quartile range, IQR]) (age 72 [65–77]; 75% males) with heart failure due to left ventricular systolic impairment undertook a 6-MWT as part of their baseline assessment and were followed up for 5 years. Results. At 5 years’ followup, those patients who died (n = 959) were older at baseline and had a higher log NT pro-BNP than those who survived to 5 years (n = 708). 6-MWT distance was lower in those who died [163 (153) m versus 269 (160) m; P < 0.0001]. Median 6-MWT distance was 300 (150–376) m, and quartile ranges were <46 m, 46–240 m, 241–360 m, and >360 m. 6-MWT distance was a predictor of all-cause mortality (HR 0.97; 95% CI 0.96-0.97; Chi-square = 184.1; P < 0.0001). Independent predictors of all-cause mortality were decreasing 6-MWT distance, increasing age, increasing NYHA classification, increasing log NT pro-BNP, decreasing diastolic blood pressure, decreasing sodium, and increasing urea. Conclusion. The 6-MWT is an important independent predictor of all-cause mortality following long-term followup in patients with CHF.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Cleland, Professor John
• Authors: Ingle, L., Cleland, J. G., and Clark, A. L.
• Subjects: R Medicine > R Medicine (General)
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre
• Journal Name: BioMed Research International
• Publisher: Hindawi Publishing Corporation
• ISSN: 2314-6133
• ISSN (Online): 2314-6141
• Copyright Holders: Copyright © 2014 Lee Ingle et al.
• First Published: First published in BioMed Research International 2014: 505969
• Publisher Policy: Reproduced under a Creative Commons License