Cancer metabolism at a glance

Vazquez, A., Kamphorst, J. J. , Markert, E. K., Schug, Z. T., Tardito, S. and Gottlieb, E. (2016) Cancer metabolism at a glance. Journal of Cell Science, 129(18), pp. 3367-3373. (doi:10.1242/jcs.181016) (PMID:27635066)

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Abstract

A defining hallmark of cancer is uncontrolled cell proliferation. This is initiated once cells have accumulated alterations in signaling pathways that control metabolism and proliferation, wherein the metabolic alterations provide the energetic and anabolic demands of enhanced cell proliferation. How these metabolic requirements are satisfied depends, in part, on the tumor microenvironment, which determines the availability of nutrients and oxygen. In this Cell Science at a Glance paper and the accompanying poster, we summarize our current understanding of cancer metabolism, emphasizing pathways of nutrient utilization and metabolism that either appear or have been proven essential for cancer cells. We also review how this knowledge has contributed to the development of anticancer therapies that target cancer metabolism.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Tardito, Mr Saverio and Schug, Dr Zachary and Markert, Dr Elke and Gottlieb, Professor Eyal and Kamphorst, Dr Jurre and Vazquez Vazquez, Alexei
Authors: Vazquez, A., Kamphorst, J. J., Markert, E. K., Schug, Z. T., Tardito, S., and Gottlieb, E.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Journal of Cell Science
Publisher:Company of Biologists
ISSN:0021-9533
ISSN (Online):1477-9137
Published Online:15 September 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Journal of Cell Science 129(18):3367-3373
Publisher Policy:Reproduced under a Creative Commons License

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