Applying chemical genetic tools to the study of phospho-signalling pathways in malaria parasites

Mitcheson, D. F., Tobin, A. B. and Alam, M. M. (2015) Applying chemical genetic tools to the study of phospho-signalling pathways in malaria parasites. Biochimica et Biophysica Acta: Proteins and Proteomics, 1854(10), pp. 1650-1656. (doi: 10.1016/j.bbapap.2015.06.014) (PMID:26143498)

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Abstract

Until very recently there has been very little information about the phospho-signalling pathways in apicomplexan parasites including the most virulent species of human malaria parasite, Plasmodium falciparum. With the advancement of mass spectrometry-based phosphoproteomics and the development of chemical genetic approaches to target specific parasite protein kinases, the complexity of the essential role played by phosphorylation in maintaining the viability of apicomplexan parasites is now being revealed. This review will describe these recent advances and will discuss how these approaches can be used to validate parasite protein kinases as drug targets and to determine the on- and off-target action of protein kinases inhibitors.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Alam, Dr Mahmood and Tobin, Andrew
Authors: Mitcheson, D. F., Tobin, A. B., and Alam, M. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Research Group:Biochemistry & Molecular Biology
Journal Name:Biochimica et Biophysica Acta: Proteins and Proteomics
Publisher:Elsevier
ISSN:1570-9639
ISSN (Online):1878-145
Published Online:02 July 2015

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