Fractional flow reserve: a clinical perspective

Corcoran, D., Hennigan, B. and Berry, C. (2017) Fractional flow reserve: a clinical perspective. International Journal of Cardiovascular Imaging, 33(7), pp. 961-974. (doi:10.1007/s10554-017-1159-2) (PMID:28577046) (PMCID:PMC5489582)

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Abstract

Fractional flow reserve (FFR) is a reference invasive diagnostic test to assess the physiological significance of an epicardial coronary artery stenosis. FFR-guided percutaneous coronary intervention in stable coronary artery disease has been assessed in three seminal clinical trials and the indications for FFR assessment are expanding into other clinical scenarios. In this article we review the theoretical, experimental and clinical basis for FFR measurement. We place FFR measurement in the context of the comprehensive invasive assessment of coronary physiology in patients presenting with known or suspected angina pectoris in daily clinical practice, and review the recent developments in FFR assessment.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Berry, Professor Colin and Corcoran, Dr David and Hennigan, Dr Barry
Authors: Corcoran, D., Hennigan, B., and Berry, C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:International Journal of Cardiovascular Imaging
Publisher:Springer
ISSN:1569-5794
ISSN (Online):1573-0743
Published Online:02 June 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in International Journal of Cardiovascular Imaging 33(7): 961-974
Publisher Policy:Reproduced under a Creative Commons license

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
628691Microvascular Dysfunction in Patients with Angina: The CE-MARC2 Microvascular SubstudyColin BerryBritish Heart Foundation (BHF)FS/14/15/30661RI CARDIOVASCULAR & MEDICAL SCIENCES
692781A prospective comparison of the diagnostic utility of invasive coronary physiological indices and quantitative perfusion MRI in patients with coronary heart disease...Keith OldroydBritish Heart Foundation (BHF)PG/14/97/31263RI CARDIOVASCULAR & MEDICAL SCIENCES