The application of phenotypic microarray analysis to anti-fungal drug development

Greetham, D., Lappin, D. F., Rajendran, R., O'Donnell, L., Sherry, L., Ramage, G. and Nile, C. (2017) The application of phenotypic microarray analysis to anti-fungal drug development. Journal of Microbiological Methods, 134, pp. 35-37. (doi:10.1016/j.mimet.2017.01.004) (PMID:28082175)

Greetham, D., Lappin, D. F., Rajendran, R., O'Donnell, L., Sherry, L., Ramage, G. and Nile, C. (2017) The application of phenotypic microarray analysis to anti-fungal drug development. Journal of Microbiological Methods, 134, pp. 35-37. (doi:10.1016/j.mimet.2017.01.004) (PMID:28082175)

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Abstract

Candida albicans metabolic activity in the presence and absence of acetylcholine was measured using phenotypic microarray analysis. Acetylcholine inhibited C. albicans biofilm formation by slowing metabolism independent of biofilm forming capabilities. Phenotypic microarray analysis can therefore be used for screening compound libraries for novel anti-fungal drugs and measuring antifungal resistance.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Lappin, Dr David and Ramage, Professor Gordon and Rajendran, Dr Ranjith and Nile, Dr Christopher and Sherry, Dr Leighann and O'Donnell, Lindsay
Authors: Greetham, D., Lappin, D. F., Rajendran, R., O'Donnell, L., Sherry, L., Ramage, G., and Nile, C.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Journal of Microbiological Methods
Publisher:Elsevier
ISSN:0167-7012
ISSN (Online):1872-8359
Published Online:09 January 2017
Copyright Holders:Copyright © 2017 Elsevier
First Published:First published in Journal of Microbiological Methods 134:35-37
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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