The digital code driven autonomous synthesis of ibuprofen automated in a 3D-printer-based robot

Kitson, P. J., Glatzel, S. and Cronin, L. (2016) The digital code driven autonomous synthesis of ibuprofen automated in a 3D-printer-based robot. Beilstein Journal of Organic Chemistry, 12, pp. 2776-2783. (doi: 10.3762/bjoc.12.276) (PMID:28144350) (PMCID:PMC5238580)

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Abstract

An automated synthesis robot was constructed by modifying an open source 3D printing platform. The resulting automated system was used to 3D print reaction vessels (reactionware) of differing internal volumes using polypropylene feedstock via a fused deposition modeling 3D printing approach and subsequently make use of these fabricated vessels to synthesize the nonsteroidal anti-inflammatory drug ibuprofen via a consecutive one-pot three-step approach. The synthesis of ibuprofen could be achieved on different scales simply by adjusting the parameters in the robot control software. The software for controlling the synthesis robot was written in the python programming language and hard-coded for the synthesis of ibuprofen by the method described, opening possibilities for the sharing of validated synthetic ‘programs’ which can run on similar low cost, user-constructed robotic platforms towards an ‘open-source’ regime in the area of chemical synthesis.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kitson, Dr Philip and Glatzel, Dr Stefan and Cronin, Professor Lee
Authors: Kitson, P. J., Glatzel, S., and Cronin, L.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Beilstein Journal of Organic Chemistry
Publisher:Beilstein-Institut
ISSN:1860-5397
ISSN (Online):1860-5397
Copyright Holders:Copyright © 2016 Kitson et al.
First Published:First published in Beilstein Journal of Organic Chemistry 12:2776-2783
Publisher Policy:Reproduced under a Creative Commons License

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