Whitfield, H. J., Griffin, R. J., Hardcastle, I. R., Henderson, A., Meneyrol, J., Mesguiche, V., Sayle, K. L. and Golding, B. T. (2003) Facilitation of addition–elimination reactions in pyrimidines and purines using trifluoroacetic acid in trifluoroethanol. Chemical Communications, 2003(22), pp. 2802-2803. (doi: 10.1039/b308948g) (PMID:14651112)
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Abstract
SNAr displacement reactions of 6-cyclohexylmethoxy-2-fluoropurine, 6-amino-2-butylsulfonyl-4-cyclohexylmethoxypyrimidine and 2-amino-6-chloropurine with substituted anilines (e.g. the weakly nucleophilic 4-aminobenzenesulfonamide) are dramatically accelerated in the presence of trifluoroacetic acid and occur especially efficiently in 2,2,2-trifluoroethanol solvent.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Sayle, Dr Kerry |
| Authors: | Whitfield, H. J., Griffin, R. J., Hardcastle, I. R., Henderson, A., Meneyrol, J., Mesguiche, V., Sayle, K. L., and Golding, B. T. |
| Subjects: | Q Science > QD Chemistry |
| College/School: | College of Science and Engineering > Scottish Universities Environmental Research Centre |
| Journal Name: | Chemical Communications |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1359-7345 |
| ISSN (Online): | 1364-548X |
| Published Online: | 14 October 2003 |
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