Prognostic burden of heart failure recorded in primary care, acute hospital admissions, or both: a population-based linked electronic health record cohort study in 2.1 million people

Koudstaal, S. et al. (2017) Prognostic burden of heart failure recorded in primary care, acute hospital admissions, or both: a population-based linked electronic health record cohort study in 2.1 million people. European Journal of Heart Failure, 19(9), pp. 1119-1127. (doi: 10.1002/ejhf.709) (PMID:28008698) (PMCID:PMC5420446)

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Aims: The prognosis of patients hospitalized for worsening heart failure (HF) is well described, but not that of patients managed solely in non-acute settings such as primary care or secondary outpatient care. We assessed the distribution of HF across levels of healthcare, and assessed the prognostic differences for patients with HF either recorded in primary care (including secondary outpatient care) (PC), hospital admissions alone, or known in both contexts. Methods and results: This study was part of the CALIBER programme, which comprises linked data from primary care, hospital admissions, and death certificates for 2.1 million inhabitants of England. We identified 89 554 patients with newly recorded HF, of whom 23 547 (26%) were recorded in PC but never hospitalized, 30 629 (34%) in hospital admissions but not known in PC, 23 681 (27%) in both, and 11 697 (13%) in death certificates only. The highest prescription rates of ACE inhibitors, beta-blockers, and mineralocorticoid receptor antagonists was found in patients known in both contexts. The respective 5-year survival in the first three groups was 43.9% [95% confidence interval (CI) 43.2–44.6%], 21.7% (95% CI 21.1–22.2%), and 39.8% (95% CI 39.2–40.5%), compared with 88.1% (95% CI 87.9–88.3%) in the age- and sex-matched general population. Conclusion: In the general population, one in four patients with HF will not be hospitalized for worsening HF within a median follow-up of 1.7 years, yet they still have a poor 5-year prognosis. Patients admitted to hospital with worsening HF but not known with HF in primary care have the worst prognosis and management. Mitigating the prognostic burden of HF requires greater consistency across primary and secondary care in the identification, profiling, and treatment of patients. Trial registration: NCT02551016.

Item Type:Articles
Additional Information:S.K. is supported by a research fellowship programme of thenon-prot organization Genetic Cardiomyopathy PLN (; A.D.S. is support ed by a clinical researchtraining fellowship from the Wellcome Trust (0938/30/Z/10/Z).F.A. is supported by a Dekker scholarship-Junior Staff Member2014T001 –Netherlands Heart Foundation and UCL HospitalsNIHR Biomedical Research Centre. The Farr Institute of HealthInformatics Research at UCL Partners is funded based on awardsfrom the Medical Research Council, Arthritis Research UK, BritishHeart Foundation, Cancer Research UK, Chief Scientist Ofce,Economic and Social Research Council, Engineering and PhysicalSciences Research Council, National Institute for Health Research,National Institute for Social Care and Health Research, and Well-come Trust (grant MR/K006584/1).
Glasgow Author(s) Enlighten ID:Cleland, Professor John
Authors: Koudstaal, S., Pujades-Rodriguez, M., Denaxas, S., Gho, J. M.I.H., Shah, A. D., Yu, N., Patel, R. S., Gale, C. P., Hoes, A. W., Cleland, J. G.F., Asselbergs, F. W., and Hemingway, H.
Subjects:R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
Journal Name:European Journal of Heart Failure
ISSN (Online):1879-0844
Published Online:23 December 2016
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in European Journal of Heart Failure 19(9):1119-1127
Publisher Policy:Reproduced under a Creative Commons License

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