Oscillatory regulation of Hes1: discrete stochastic delay modelling and simulation

Barrio, M., Burrage, K., Leier, A. and Tian, T. (2006) Oscillatory regulation of Hes1: discrete stochastic delay modelling and simulation. PLoS Computational Biology, 2(9), e117. (doi:10.1371/journal.pcbi.0020117)

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Discrete stochastic simulations are a powerful tool for understanding the dynamics of chemical kinetics when there are small-to-moderate numbers of certain molecular species. In this paper we introduce delays into the stochastic simulation algorithm, thus mimicking delays associated with transcription and translation. We then show that this process may well explain more faithfully than continuous deterministic models the observed sustained oscillations in expression levels of hes1 mRNA and Hes1 protein.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Tian, Dr Tianhai
Authors: Barrio, M., Burrage, K., Leier, A., and Tian, T.
College/School:College of Science and Engineering > School of Mathematics and Statistics > Mathematics
Journal Name:PLoS Computational Biology
Publisher:Public Library of Science
ISSN (Online):1553-7358
Published Online:08 September 2006
First Published:First published in PLoS Computational Biology 2(9):e117
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher.

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