Oscillatory regulation of Hes1: discrete stochastic delay modelling and simulation

Barrio, M., Burrage, K., Leier, A. and Tian, T. (2006) Oscillatory regulation of Hes1: discrete stochastic delay modelling and simulation. PLoS Computational Biology, 2(9), e117. (doi: 10.1371/journal.pcbi.0020117)

Abstract

Discrete stochastic simulations are a powerful tool for understanding the dynamics of chemical kinetics when there are small-to-moderate numbers of certain molecular species. In this paper we introduce delays into the stochastic simulation algorithm, thus mimicking delays associated with transcription and translation. We then show that this process may well explain more faithfully than continuous deterministic models the observed sustained oscillations in expression levels of hes1 mRNA and Hes1 protein.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Tian, Dr Tianhai
• Authors: Barrio, M., Burrage, K., Leier, A., and Tian, T.
• College/School: College of Science and Engineering > School of Mathematics and Statistics > Mathematics
• Journal Name: PLoS Computational Biology
• Publisher: Public Library of Science
• ISSN: 1553-734X
• ISSN (Online): 1553-7358
• Published Online: 08 September 2006
• First Published: First published in PLoS Computational Biology 2(9):e117
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher.