Todd, A. J. (2017) Identifying functional populations among the interneurons in laminae I-III of the spinal dorsal horn. Molecular Pain, 13, pp. 1-19. (doi: 10.1177/1744806917693003) (PMID:28326935) (PMCID:PMC5315367)
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Abstract
The spinal dorsal horn receives input from primary afferent axons, which terminate in a modality-specific fashion in different laminae. The incoming somatosensory information is processed through complex synaptic circuits involving excitatory and inhibitory interneurons, before being transmitted to the brain via projection neurons for conscious perception. The dorsal horn is important, firstly because changes in this region contribute to chronic pain states, and secondly because it contains potential targets for the development of new treatments for pain. However, at present, we have only a limited understanding of the neuronal circuitry within this region, and this is largely because of the difficulty in defining functional populations among the excitatory and inhibitory interneurons. The recent discovery of specific neurochemically defined interneuron populations, together with the development of molecular genetic techniques for altering neuronal function in vivo, are resulting in a dramatic improvement in our understanding of somatosensory processing at the spinal level.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Todd, Professor Andrew |
Authors: | Todd, A. J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
Journal Name: | Molecular Pain |
Publisher: | SAGE |
ISSN: | 1744-8069 |
ISSN (Online): | 1744-8069 |
Published Online: | 01 February 2017 |
Copyright Holders: | Copyright © 2017 The Authors |
First Published: | First published in Molecular Pain 13:1-19 |
Publisher Policy: | Reproduced under a Creative Commons License |
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