Cardiopulmonary exercise testing in children with cystic fibrosis: one centre's experience

Weir, E., Burns, P. D., Devenny, A., Young, D. and Paton, J. Y. (2017) Cardiopulmonary exercise testing in children with cystic fibrosis: one centre's experience. Archives of Disease in Childhood, 102(5), pp. 440-444. (doi: 10.1136/archdischild-2016-310651) (PMID:27919886)

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Abstract

Background: While exercise testing is increasingly used as a prognostic indicator in cystic fibrosis (CF), it is reported to be underused in UK CF centres, particularly in children. Here, we evaluated the cardiopulmonary exercise testing (CPET) results in children and young people with CF at CF annual review and its possible clinical value. Method: An observational study comparing CPET results using a cycle ergometer ramp test (peak oxygen uptake (Vo2peak)) and pulmonary function (forced expiratory volume in 1 s (FEV1)) was performed with body mass index (BMI) used as a disease severity marker. Data were identified from clinical case notes and our CF database. Results: Thirty-eight children and young people (mean age 11±2.4, range 7–14 years; 17 males and 21 females) completed at least one CPET with 95% achieving technically satisfactory tests allowing measurement of Vo2peak. Mean Vo2peak was 107 ±17.6% predicted, range 74%–150% predicted, with 8% having a reduced Vo2peak of <85% of predicted. Mean FEV1 z-score was −0.77±1.24, range −4.42 to 2.24. We did not demonstrate a significant correlation between Vo2peak % predicted and FEV1 z-score (r=0.25, p=0.13), or between Vo2peak % predicted and BMI z-score (r=−0.05, p=0.77). Twenty-eight of 38 completed a second CPET the following year with 71% showing a decline in Vo2peak (mean decline of 8% of predicted value, equivalent to 3.8 mL/kg/min). Conclusion: CPET is feasible with 95% of children and young people achieving technically satisfactory assessments starting from age 7. In this group with relatively mild CF, mean Vo2peak was normal with no significant correlation between Vo2peak and FEV1 or BMI, as markers of disease severity. The majority demonstrated a normal Vo2peak. However, 71% showed a downward trend on repeat testing 12–18 months later.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Paton, Dr James and Devenny, Dr Anne
Authors: Weir, E., Burns, P. D., Devenny, A., Young, D., and Paton, J. Y.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Archives of Disease in Childhood
Publisher:BMJ Publishing Group
ISSN:0003-9888
ISSN (Online):1468-2044
Published Online:05 December 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Archives of Disease in Childhood 102(5):440-444
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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